Back to search

Article

Risk factors mediating the effect of body-mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis

2020-07-16

Abstract excerpt

<h4>Background</h4> Higher body-mass index (BMI) and waist-to-hip ratio (WHR) increase the risk of cardiovascular disease, but the extent to which this is mediated by blood pressure, diabetes, lipid traits and smoking is not fully understood. <h4>Methods</h4> Using consortia and UK Biobank genetic association summary data from 140,595 to 898,130 participants predominantly of European ancestry, MR mediation analysi...

Identifiers and source

Literature Corpus work
3f3f71c4-587e-5a6b-a73a-4a2f4b334fbc
DOI
10.1101/2020.07.15.20154096
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Risk factors mediating the effect of body-mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysisDOI 10.1101/2020.07.15.20154096
Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysisSemantic proximity
Analyses of potential causal contributors to increased waist/hip ratio-associated cardiometabolic disease: A combined and sex-stratified Mendelian randomization study.Semantic proximity
Causal relevance of obesity on the leading causes of death in women and men: A Mendelian randomization studySemantic proximity
Causal relationships between obesity and the leading causes of death in women and men.Semantic proximity
The role of glycaemic, lipid, blood pressure and obesity risk factors as mediators of the effect of height on Coronary Artery Disease and Type 2 Diabetes Mellitus: A Mendelian Randomisation StudySemantic proximity
Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.Semantic proximity
The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization studySemantic proximity
Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization studySemantic proximity
Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.Semantic proximity
Exploring the causal effects of physical activity, diet, and nutrition on hypertension and hyperlipidemia: a multivariable Mendelian randomization analysis.Semantic proximity
Causal associations between type 1 diabetes mellitus and cardiovascular diseases: A Mendelian randomization studySemantic proximity
Causal Effect of Adiposity Measures on Blood Pressure Traits in 2 Urban Swedish Cohorts: A Mendelian Randomization Study.Semantic proximity
Select a neighboring publication to make it the new centre.