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Article

Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach.

BMC bioinformatics - 13 Oct 2022

Ding Zhuoran, Ritchie Marylyn D, Voight Benjamin F, Hwang Wei-Ting

Abstract excerpt

BACKGROUND: Observational studies and Mendelian randomization experiments have been used to identify many causal factors for complex traits in humans. Given a set of causal factors, it is important to understand the extent to which these causal factors explain some, all, or none of the genetic heritability, as measured by single-nucleotide polymorphisms (SNPs) that are associated with the trait. Using the...

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PMID: 36229773
DOI: 10.1186/s12859-022-04977-4
PMCID: PMC9559019

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