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Article

Mendelian randomisation for mediation analysis: current methods and challenges for implementation.

European journal of epidemiology - 1 May 2021

Carter Alice R, Sanderson Eleanor, Hammerton Gemma, Richmond Rebecca C, Davey Smith George, Heron Jon, Taylor Amy E, Davies Neil M, Howe Laura D

Abstract excerpt

Mediation analysis seeks to explain the pathway(s) through which an exposure affects an outcome. Traditional, non-instrumental variable methods for mediation analysis experience a number of methodological difficulties, including bias due to confounding between an exposure, mediator and outcome and measurement error. Mendelian randomisation (MR) can be used to improve causal inference for mediation analysis. We...

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Identifiers

PMID: 33961203
DOI: 10.1007/s10654-021-00757-1
PMCID: PMC8159796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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