Article
The identification of mediating effects using genome-based restricted maximum likelihood estimation.
PLoS genetics - 1 Feb 2023
Rietveld Cornelius A, de Vlaming Ronald, Slob Eric A W
Abstract excerpt
Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates the relationship between the genetic component of outcome Y and outcome Y itself. However, this approach suffers from attenuation bias, as PGSs capture only a (small)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.