Article

Structure-based mechanism of RyR channel operation by calcium and magnesium ions

2024-08-01

Abstract excerpt

Ryanodine receptors (RyRs) serve for excitation-contraction coupling in skeletal and cardiac muscle cells in a noticeably different way, not fully understood at the molecular level. We addressed the structure of skeletal (RyR1) and cardiac (RyR2) isoforms relevant to gating by Ca 2+ and Mg 2+ ions (M 2+ ). Bioinformatics analysis of RyR structures ascertained the EF-hand loops as the M 2+ binding inhibition si...

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Literature Corpus work: 9224c5fd-cb98-50a5-9985-9eeccf14cc77
DOI: 10.1101/2024.08.01.606133

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