Article

A <i>Plasmodium falciparum</i> redox survival mechanism licenses killing by artemisinins

2025-10-08

Abstract excerpt

Mutations in Plasmodium falciparum Kelch13 (K13) confer artemisinin resistance (ART-R) which threatens global malaria control, but known K13 functions fail to explain clinical ART-R. We reported that K13 binds the oxidant heme in vitro , however, its functions in redox-stress, cell survival and death remained unknown. Since taut control of free heme is not feasible in infected erythrocytes, we utilized a non-ery...

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Literature Corpus work: 91ff8d75-17b7-55cc-abf7-4564c5601456
DOI: 10.1101/2025.10.08.681084

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