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Artemisinin-resistant <i>Plasmodium falciparum</i> Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

2024-01-24

Abstract excerpt

The rapid emergence of artemisinin resistance (ART-R) poses a challenge to global malaria control efforts. ART potency is triggered by ferrous iron- and/or heme-mediated cleavage of the endoperoxide bond to generate reactive heme-ART alkoxy radicals and covalent heme-ART adducts that alkylate parasite targets or inhibit the detoxification of heme into β-hematin crystals; both of which lead to parasite death. Mutat...

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Literature Corpus work
d4fcd74e-20b7-5e30-83f5-ef49eea26620
DOI
10.1101/2024.01.23.576340
Open publication

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Artemisinin-resistant <i>Plasmodium falciparum</i> Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activationDOI 10.1101/2024.01.23.576340
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