Article
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival.
Nature communications - 22 Jan 2021
Mok Sachel, Stokes Barbara H, Gnädig Nina F, Ross Leila S, Yeo Tomas, Amaratunga Chanaki, Allman Erik, Solyakov Lev, Bottrill Andrew R, Tripathi Jaishree, Fairhurst Rick M, Llinás Manuel, Bozdech Zbynek, Tobin Andrew B, Fidock David A
Abstract excerpt
The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, and metabolomics to a panel of isogenic K13 mutant or wild-type P. falciparum lines, we provide evidence that K13 mutations alter multiple aspects of the...
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