Article
Peroxide antimalarial drugs target redox homeostasis in <i>Plasmodium falciparum</i> infected red blood cells
2021-09-11
Abstract excerpt
Plasmodium falciparum causes the most lethal form of malaria. Peroxide antimalarials based on artemisinin underpin the frontline treatments for malaria, but artemisinin resistance is rapidly spreading. Synthetic peroxide antimalarials, known as ozonides, are in clinical development and offer a potential alternative. Here, we used chemoproteomics to investigate the protein alkylation targets of artemisinin and ozon...
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Identifiers and source
- Literature Corpus work
- 24c9f404-6e5f-546f-86a9-2452dd27b8db
- DOI
- 10.1101/2021.09.10.459878