Article

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

2021-09-30

Abstract excerpt

<h4>Summary</h4> Cholinergic and sympathetic counter-regulatory networks control numerous physiologic functions including learning/memory/cognition, stress responsiveness, blood pressure, heart rate and energy balance. As neurons primarily utilize glucose as their primary metabolic energy source, we generated mice with increased glycolysis in cholinergic neurons by specific deletion of the fructose-2,6-phosphatas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91f54ffd-ff06-5838-bb90-e4d96f293d7f
DOI: 10.1101/2021.09.28.462124

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junctionDOI 10.1101/2021.09.28.462124Read

Weak neuronal glycolysis sustains cognition and organismal fitnessSemantic proximity Read

A mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.Semantic proximity Read

NAD homeostasis maintained by NMNAT2 supports vesicular glycolysis and fuels fast axonal transport in distal axons of cortical glutamatergic neurons in miceSemantic proximity Read

Neuronal glycolytic reprogramming drives lethality via accelerated aging in a <i>Drosophila</i> model of tauopathySemantic proximity Read

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transportSemantic proximity Read

Cholinergic Phenotypes of Acetyl-CoA with ATP-Citrate Lyase Link.Semantic proximity Read

Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.Semantic proximity Read

Low-salt Diet Regulates the Metabolic and Signal Transduc-tion Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological PathwaysSemantic proximity Read

Tweaking energy metabolism to prevent and treat neurological disorders.Semantic proximity Read

Astrocytic glycogenolysis gates Warburg-like metabolic reprogramming that promotes neuropathic pain chronificationSemantic proximity Read

DDHD2 is necessary for activity-driven fatty acid fueling of nerve terminal functionSemantic proximity Read

ADO-MEDIATED SYNTHESIS OF TAURINE ALTERS THE CHROMATIN LANDSCAPE OF INGUINAL ADIPOSE TISSUE TO ENHANCE NON-SHIVERING THERMOGENESISSemantic proximity Read