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Article

Cholinergic Phenotypes of Acetyl-CoA with ATP-Citrate Lyase Link.

International journal of molecular sciences - 13 Jan 2026

Gul-Hinc Sylwia, Jankowska-Kulawy Agnieszka, Szutowicz Andrzej

Abstract excerpt

Glycolysis-derived pyruvate is the almost exclusive source of acetyl-CoA for energy production in mitochondrial compartments of all types of neuronal and glial cells. Neurons utilize several times more glucose than glial cells due to their neurotransmitter functions. Cholinergic neurons that are responsible for cognitive functions require additional amounts of acetyl-CoA for acetylcholine-transmitter synthesis in...

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Identifiers

PMID: 41596431
DOI: 10.3390/ijms27020782
PMCID: PMC12840816

Genes

ACLY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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