Article

Astrocytic glycogenolysis gates Warburg-like metabolic reprogramming that promotes neuropathic pain chronification

2025-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Chronic pain remains a major unmet medical challenge, yet the metabolic checkpoints that govern its persistence are poorly defined. Astrocytes are increasingly recognized as chemically programmable hubs that tune neuronal excitability through metabolic circuits. Building on reports that astrocyte–neuron lactate shuttling (ANLS) in the anterior cingulate cortex (ACC) supports chronic pain, we ask...

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Literature Corpus work: 280503bd-f8a7-5296-8eeb-e6758ac8a100
DOI: 10.1101/2025.05.27.655245

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