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Article

Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.

PLoS genetics - 1 Oct 2021

Jeong Jiwon, Lee Jongbin, Kim Ji-Hyung, Lim Chunghun

Abstract excerpt

Kohlschütter-Tönz syndrome (KTS) manifests as neurological dysfunctions, including early-onset seizures. Mutations in the citrate transporter SLC13A5 are associated with KTS, yet their underlying mechanisms remain elusive. Here, we report that a Drosophila SLC13A5 homolog, I'm not dead yet (Indy), constitutes a neurometabolic pathway that suppresses seizure. Loss of Indy function in glutamatergic neurons caused...

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Identifiers

PMID: 34714823
DOI: 10.1371/journal.pgen.1009871
PMCID: PMC8555787

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