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MRCKα/CDC42BPA Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular Cells

2025-09-18

Abstract excerpt

Pro-fibrotic mediators derived from tubular cells have a central role in he development of kidney fibrosis. Our previous studies revealed that GEF-H1 (ARHGEF2)/RhoA signalling is a crucial regulator of tubular mediator release. Fibrotic stimuli elevate GEF-H1 expression and activity, but the molecular mechanisms controlling tubular GEF-H1 activity during fibrotic reprogramming are incompletely explored. Here we us...

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Literature Corpus work
91ed2d5f-6fa7-5691-970c-441e89ea8479
DOI
10.20944/preprints202509.1567.v1
Open publication

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MRCKα/CDC42BPA Is a Suppressor of GEF-H1/RhoA/MRTF Signaling in Tubular CellsDOI 10.20944/preprints202509.1567.v1
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