Article
Central role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.
Molecular biology of the cell - 1 Apr 2013
Waheed Faiza, Dan Qinghong, Amoozadeh Yasaman, Zhang Yuqian, Tanimura Susumu, Speight Pam, Kapus András, Szászi Katalin
Abstract excerpt
Transactivation of the epidermal growth factor receptor (EGFR) by tumor necrosis factor-α (TNF-α) is a key step in mediating RhoA activation and cytoskeleton and junction remodeling in the tubular epithelium. In this study we explore the mechanisms underlying TNF-α-induced EGFR activation. We show that TNF-α stimulates the TNF-α convertase enzyme (TACE/a disintegrin and metalloproteinase-17), leading to...
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