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Article

Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney disease

2024-03-17

Abstract excerpt

Polycystic kidney disease (PKD) is characterized by extensive cyst formation and progressive fibrosis. However, the molecular mechanisms whereby the loss/loss-of-function of Polycystin 1 or 2 (PC1/2) provokes fibrosis are largely unknown. The small GTPase RhoA has been recently implicated in cystogenesis , and we have shown that the RhoA/cytoskeleton/myocardin-related transcription factor (MRTF) pathway is a key...

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Literature Corpus work
8ad09d43-2cf2-5651-a1ca-16a83bffffb5
DOI
10.1101/2024.03.15.585204
Open publication

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Myocardin-related transcription factor drives epithelial fibrogenesis in polycystic kidney diseaseDOI 10.1101/2024.03.15.585204
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