MRTF: Basic Biology and Role in Kidney Disease

doi:10.3390/ijms22116040

Article

MRTF: Basic Biology and Role in Kidney Disease

3 Jun 2021

Abstract excerpt

A lesser known but crucially important downstream effect of Rho family GTPases is the regulation of gene expression. This major role is mediated via the cytoskeleton, the organization of which dictates the nucleocytoplasmic shuttling of a set of transcription factors. Central among these is myocardin-related transcription factor (MRTF), which upon actin polymerization translocates to the nucleus and binds to its...

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