Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations.

doi:10.1038/s41467-022-35639-x

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Article

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations.

Nature communications - 22 Dec 2022

Le Dour Caroline, Chatzifrangkeskou Maria, Macquart Coline, Magiera Maria M, Peccate Cécile, Jouve Charlène, Virtanen Laura, Heliö Tiina, Aalto-Setälä Katriina, Crasto Silvia, Cadot Bruno, Cardoso Déborah, Mougenot Nathalie, Adesse Daniel, Di Pasquale Elisa, Hulot Jean-Sébastien, Taimen Pekka, Janke Carsten, Muchir Antoine

Abstract excerpt

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates cofilin-1 on threonine 25 (phospho(T25)-cofilin-1) that in turn disassembles the actin cytoskeleton. Here, we show that in muscle cells carrying a cardiomyopathy-causing LMNA mutation, phospho(T25)-cofilin-1 binds to myocardin-related...

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Identifiers

PMID: 36550158
DOI: 10.1038/s41467-022-35639-x
PMCID: PMC9780334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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