Article

Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril Core

2025-11-03

Abstract excerpt

Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ 1-42 fibrils remain unresolved. Using magic-angle spinning nuclear magnetic resonance, we show that binding of aducanumab preserves the overall architecture of the Aβ 1-42 fibril core while inducing sign...

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Identifiers and source

Literature Corpus work: 91c630c1-9330-5a42-b4ba-893c46403af9
DOI: 10.1101/2025.11.01.686027

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Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril CoreDOI 10.1101/2025.11.01.686027Read

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