Article

Engineering a Dimeric Single-Domain Antibody for Improved Detection and neutralization of Amyloid-β Oligomers

2025-08-31

Abstract excerpt

Soluble Aβ oligomers are regarded as major neurotoxic agents in Alzheimer’s disease. Several monoclonal antibodies have been developed to target Aβ oligomers, but most of them show limited specificity binding also to monomers and fibrils. To generate an antibody with high specificity for the oligomers, we aimed to increase the efficiency and sensitivity of a humanized Aβ-oligomer-specific single domain antibody, c...

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Literature Corpus work: 256061eb-2654-57fc-b1fc-4d5102d4bb4c
DOI: 10.1101/2025.08.29.672921

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