Article

Anti-amyloid antibody effects on Aβ-42 protein aggregates profiled using nanospectroscopy

2025-07-21

Abstract excerpt

Anti-amyloid beta (Aβ) drugs such as aducanumab and lecanemab are designed to clear brain amyloids and slow Alzheimer’s disease (AD) progression. While immunoassays provide ensemble-level details on anti-Aβ drug interactions with protein targets, their interfacial effects are largely unknown at a single-particle level. Here, we profile untreated and aducanumab-treated Aβ-42 protein aggregates from oligomers to fib...

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Literature Corpus work: 8b4405fd-adfb-5c42-bc13-98c0b1d77efc
DOI: 10.1101/2025.07.17.665305

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