Article

Molecular mechanisms underlying amyloid lowering by aducanumab: differential and comparative effects of sex and IgG reveal the post-treatment disease brain

2026-06-21

Abstract excerpt

<h4>INTRODUCTION</h4> Improving the predictive validity of preclinical studies for Alzheimer’s disease (AD) requires rigorous evaluation of therapeutic efficacy, safety, and sex-specific responses in translationally relevant models. As amyloid-targeting monoclonal antibodies continue to advance clinically, there is an urgent need to define the molecular milieu that persists after amyloid is reduced and disease pr...

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Literature Corpus work: 3841b003-a7ad-5f9c-b70b-b975c91b9790
DOI: 10.64898/2026.06.16.731973

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