Article
Atomic-resolution three-dimensional structure of amyloid β fibrils bearing the Osaka mutation.
Angewandte Chemie (International ed. in English) - 2 Jan 2015
Schütz Anne K, Vagt Toni, Huber Matthias, Ovchinnikova Oxana Y, Cadalbert Riccardo, Wall Joseph, Güntert Peter, Böckmann Anja, Glockshuber Rudi, Meier Beat H
Abstract excerpt
Despite its central importance for understanding the molecular basis of Alzheimer's disease (AD), high-resolution structural information on amyloid β-peptide (Aβ) fibrils, which are intimately linked with AD, is scarce. We report an atomic-resolution fibril structure of the Aβ1-40 peptide with the Osaka mutation (E22Δ), associated with early-onset AD. The structure, which differs substantially from all previously...
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