Article

Aggregation-Dependent Epitope Sequence and Modification Fingerprints of Anti-Aβ Antibodies

2025-03-03

Abstract excerpt

A hallmark of Alzheimer’s disease (AD), the most common form of dementia, is the progressive accumulation of amyloid-beta (Aβ) peptides across distinct brain regions. Anti-Aβ antibodies (Aβ-Abs) targeting specific Aβ variants are essential tools for AD research, diagnostics, and therapy. The monoclonal antibodies Aducanumab, Lecanemab, and Donanemab have recently been approved as the first disease-modifying treatm...

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Literature Corpus work: 5fb32654-6e90-5c53-a5c3-2f28f82f9d6b
DOI: 10.1101/2025.02.26.640323

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