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Article

Antibody-receptor interactions mediate antibody-dependent cellular cytotoxicity.

The Journal of biological chemistry - 1 Jul 2021

Sun Yue, Izadi Saeed, Callahan Matthew, Deperalta Galahad, Wecksler Aaron T

Abstract excerpt

Binding of antibodies to their receptors is a core component of the innate immune system. Understanding the precise interactions between antibodies and their Fc receptors has led to the engineering of novel mAb biotherapeutics with tailored biological activities. One of the most significant findings is that afucosylated monoclonal antibodies demonstrate increased affinity toward the receptor FcγRIIIa, with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34044019
DOI: 10.1016/j.jbc.2021.100826
PMCID: PMC8214220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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