Article

Kat5 cKO Biological Domain Signatures Align with Human Alzheimer’s Disease

2025-09-17

Abstract excerpt

<h4>BACKGROUND</h4> Alzheimer’s disease (AD) is associated with amyloid plaques and can be caused by autosomal dominant mutations in APP or PSEN1/2, which form an enzyme substrate complex. Decreases in catalysis of AD mutant APP and PSEN1 supports the hypothesis that membrane delimitation of KAT5 could contribute to AD. <h4>METHODS</h4> We compare the hippocampal transcriptome profiles of the Kat5 brain-specific...

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Literature Corpus work: 2c891835-8b9e-5ea9-a935-9f4a637fadbf
DOI: 10.1101/2025.09.13.676046

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