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Article

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease

11 Dec 2015

Abstract excerpt

Adenosine to inosine (A-to-I) RNA editing, catalyzed by the ADAR enzyme family, acts on dsRNA structures within pre-mRNA molecules. Editing of the coding part of the mRNA may lead to recoding, amino acid substitution in the resulting protein, possibly modifying its biochemical and biophysical properties. Altered RNA editing patterns have been observed in various neurological pathologies. Here, we present a...

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PMID: 26655226
DOI: 10.1261/rna.054627.115

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