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Article

Dysregulation of RNA Splicing in Tauopathies

1 Dec 2019

Abstract excerpt

Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer's disease brain tissues. The dysregulated splicing particularly affects genes involved in synaptic transmission. The effects of neuroprotective TIA1 reduction on PS19 mice are also examined. TIA1 reduction reduces disease-linked alternative splicing events for...

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PMID: 31875547
DOI: 10.1016/j.celrep.2019.11.093

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