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Engineered probiotic <i>Escherichia coli</i> -mediated intestinal nicotine clearance alleviates nonalcoholic steatohepatitis in mice

2026-07-03

Abstract excerpt

Nicotine accumulates in the gut and drives non-alcoholic steatohepatitis (NASH) via the gut-liver axis, yet no effective clinical intervention is currently available. To address this challenge, the probiotic Escherichia coli Nissle 1917 (EcN) was engineered for in situ nicotine clearance in the gut. Mutational screening of nicotine oxidoreductase 2 (PpNicA2) identified a highly active variant, PpNicA2 A107R . It...

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Identifiers and source

Literature Corpus work
91980e71-c320-57e0-8d4c-5b54da939b9f
DOI
10.64898/2026.07.02.736048
Open publication

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Engineered probiotic <i>Escherichia coli</i> -mediated intestinal nicotine clearance alleviates nonalcoholic steatohepatitis in miceDOI 10.64898/2026.07.02.736048
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