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Bioengineered Escherichia coli Nissle 1917 Mitigates Intestinal Inflammation in a Porcine Model of DSS-induced Colitis

2026-01-23

Abstract excerpt

<title>Abstract</title> <p> The probiotic <italic>Escherichia coli</italic> Nissle 1917 (EcN) is effective in the maintenance of remission in ulcerative colitis (UC), similar to 5-ASA therapy, but has equivocal efficacy in inducing remission probably due to failure to colonize the inflamed intestine. We engineered EcN, by insertion of a <italic>ttr</italic> operon (from <italic>Salmonella enterica</italic>...

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Literature Corpus work
685301bf-d401-5a16-853b-d06dca3dd7a9
DOI
10.21203/rs.3.rs-8672274/v1
Open publication

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Bioengineered Escherichia coli Nissle 1917 Mitigates Intestinal Inflammation in a Porcine Model of DSS-induced ColitisDOI 10.21203/rs.3.rs-8672274/v1
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