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Construction of an engineered <i>Escherichia coli</i> with enhanced intestinal colonization and anti-inflammatory efficacy in colitis

2025-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Engineered probiotics are considered as effective and safe therapeutic strategies for the treatment of various diseases. Escherichia coli Nissle 1917 (EcN) has been widely used as a chassis strain for its safety and well-established genetic manipulation system. The limited intestinal colonization ability of EcN hampers its potential as a chassis for constructing synthetic probiotics in therapeu...

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Identifiers and source

Literature Corpus work
05833f27-1fc5-5ffb-ae40-c117193d6e9f
DOI
10.1101/2025.08.01.668021
Open publication

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