Article

Insulated expression of periplasmic uricase in <i>E. coli</i> Nissle 1917 for the treatment of hyperuricemia

2022-04-18

Abstract excerpt

Hyperuricemia is a prevalent disease worldwide that is characterized by elevated urate levels in the blood owing to purine metabolic disorders, which can result in gout and comorbidities. As approximately one-third of urate is excreted by the small intestine and cleared by intestinal microorganisms, modulating the gut microbiota could be an attractive approach for hyperuricemia and gout treatment. In this study, w...

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Literature Corpus work: b141c688-eeec-5975-8c7f-ab39e19841b3
DOI: 10.1101/2022.04.17.488604

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