Article

Engineered spermidine-secreting <i>Saccharomyces boulardii</i> ameliorate colitis and colon cancer in mice

2025-01-19

Abstract excerpt

Experimental studies suggest that the probiotic yeast Saccharomyces boulardii can mitigate the symptoms of inflammatory bowel disease. However, these results are equivocal and S boulardii probiotic therapy has not gained widespread acceptance in clinical practice. To assess whether the therapeutic properties of S boulardii might be improved upon, we engineered S boulardii to overproduce and secrete spermidine,...

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Literature Corpus work: b97cc4f7-0a0b-5a89-b5d8-ea3c7a5e4151
DOI: 10.1101/2025.01.19.633601

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