Article

A <i>nadA</i> mutation confers nicotinic acid auxotrophy in pro-carcinogenic intestinal <i>Escherichia coli</i> NC101

2021-02-13

Abstract excerpt

Inflammatory bowel diseases and inflammation-associated colorectal cancer are linked to blooms of adherent-invasive Escherichia coli (AIEC) in the intestinal microbiota. AIEC are functionally defined by their ability to adhere/invade epithelial cells and survive/replicate within macrophages. Changes in micronutrient availability can alter AIEC physiology and interactions with host cells. Thus, culturing AIEC for...

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Literature Corpus work: 81d0cc15-afdd-5c2b-814f-d583515559e5
DOI: 10.1101/2021.02.12.431052

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