Article
Cancer treatment monitoring using cell-free DNA fragmentomes.
Nature communications - 21 Oct 2024
van 't Erve Iris, Alipanahi Bahar, Lumbard Keith, Skidmore Zachary L, Rinaldi Lorenzo, Millberg Laurel K, Carey Jacob, Chesnick Bryan, Cristiano Stephen, Portwood Carter, Wu Tony, Peters Erica, Bolhuis Karen, Punt Cornelis J A, Tom Jennifer, Bach Peter B, Dracopoli Nicholas C, Meijer Gerrit A, Scharpf Robert B, Velculescu Victor E, Fijneman Remond J A, Leal Alessandro
Abstract excerpt
Circulating cell-free DNA (cfDNA) assays for monitoring individuals with cancer typically rely on prior identification of tumor-specific mutations. Here, we develop a tumor-independent and mutation-independent approach (DELFI-tumor fraction, DELFI-TF) using low-coverage whole genome sequencing to determine the cfDNA tumor fraction and validate the method in two independent cohorts of patients with colorectal or...
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