Article

Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart

2023-09-26

Abstract excerpt

Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase contractility in the human heart. Therefore, we have generated mice that overexpress the human D 1 -dopamine receptor in the heart (D 1 -TG) and hypothesized that dopamine increases force of contraction and beating rate compared to wild type mice (WT). In D 1 -TG hearts,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91850227-bb4a-5d32-bc73-b912e06d4967
DOI: 10.21203/rs.3.rs-3363569/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heartDOI 10.21203/rs.3.rs-3363569/v1Read

Transgenic mice carrying the human beta 2-adrenergic receptor gene with its own promoter overexpress beta 2-adrenergic receptors in liver.Semantic proximity Read

A novel contractile phenotype with cardiac transgenic expression of the human P2X4 receptor.Semantic proximity Read

Constitutive Activity of the Human β1-Adrenergic Receptor in β1-Receptor Transgenic MiceSemantic proximity Read

Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor.Semantic proximity Read

Altered function in atrium of transgenic mice overexpressing triadin 1.Semantic proximity Read

Generation and characterization of hD5 and C-terminal Mutant hD(5m) transgenic rats.Semantic proximity Read

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.Semantic proximity Read

Alteration of catecholamine phenotype in transgenic mice influences expression of adrenergic receptor subtypes.Semantic proximity Read

Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects.Semantic proximity Read

Cardiac ErbB-1/ErbB-2 mutant expression in young adult mice leads to cardiac dysfunction.Semantic proximity Read

Dopamine release is impaired in a mouse model of DYT1 dystonia.Semantic proximity Read

Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta.Semantic proximity Read