Article
Alteration of catecholamine phenotype in transgenic mice influences expression of adrenergic receptor subtypes.
Journal of neurochemistry - 1 Aug 1995
Kobayashi K, Ota A, Togari A, Morita S, Mizuguchi T, Sawada H, Yamada K, Nagatsu I, Matsumoto S, Fujita K
Abstract excerpt
Agonist-induced regulation of adrenergic receptors (ARs) has an important role in controlling physiological functions in response to changes in catecholamine stimulation. We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the...
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