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Article

Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor.

Science (New York, N.Y.) - 22 Apr 1994

Milano C A, Allen L F, Rockman H A, Dolber P C, McMinn T R, Chien K R, Johnson T D, Bond R A, Lefkowitz R J

Abstract excerpt

Transgenic mice were created with cardiac-specific overexpression of the beta 2-adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgeni...

Topics

Adenylyl Cyclases
Animals
Gene Transfer Techniques
Genetic Therapy
Heart Failure
Heart Rate
Humans
Isoproterenol
Mice
Mice, Transgenic
Myocardial Contraction
Myocardium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myosins

Phenotype

Promoter Regions, Genetic

Receptors, Adrenergic, beta

Ventricular Function, Left

Source

Identifiers

PMID: 8160017
DOI: 10.1126/science.8160017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8160017-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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