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Article

Dopamine release is impaired in a mouse model of DYT1 dystonia.

Journal of neurochemistry - 1 Aug 2007

Balcioglu Aygul, Kim Mee-Ohk, Sharma Nutan, Cha Jang-Ho, Breakefield Xandra O, Standaert David G

Abstract excerpt

Early onset torsion dystonia, the most common form of hereditary primary dystonia, is caused by a mutation in the TOR1A gene, which codes for the protein torsinA. This form of dystonia is referred to as DYT1. We have used a transgenic mouse model of DYT1 dystonia [human mutant-type (hMT)1 mice] to examine the effect of the mutant human torsinA protein on striatal dopaminergic function. Analysis of striatal tissue...

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PMID: 17550429
DOI: 10.1111/j.1471-4159.2007.04590.x

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