Article
In vivo analysis of a new R5 tropic SHIV generated from the highly pathogenic SHIV-KS661, a derivative of SHIV-89.6.
Virology - 30 Mar 2010
Matsuda Kenta, Inaba Katsuhisa, Fukazawa Yoshinori, Matsuyama Megumi, Ibuki Kentaro, Horiike Mariko, Saito Naoki, Hayami Masanori, Igarashi Tatsuhiko, Miura Tomoyuki
Abstract excerpt
Although X4 tropic SHIVs have been studied extensively, they show distinct infection phenotypes from those of R5 tropic viruses, which play an important role in HIV-1 transmission and pathogenesis. To augment the variety of R5 tropic SHIVs, we generated a new R5 tropic SHIV from the highly pathogenic X4 tropic SHIV-KS661, a derivative of SHIV-89.6. Based on consensus amino acid alignment analyses of subtype B R5...
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