Article
Viral evolution in macaques coinfected with CCR5- and CXCR4-tropic SHIVs in the presence or absence of vaccine-elicited anti-CCR5 SHIV neutralizing antibodies.
Virology - 25 Nov 2006
Burke Brian, Derby Nina R, Kraft Zane, Saunders Cheryl J, Dai Chuanbin, Llewellyn Nicholas, Zharkikh Irina, Vojtech Lucia, Zhu Tuofu, Srivastava Indresh K, Barnett Susan W, Stamatatos Leonidas
Abstract excerpt
Macaques were immunized with SF162 Env-based gp140 immunogens and challenged simultaneously with the CCR5-tropic homologous SHIV(SF162P4) and the CXCR4-tropic heterologous SHIV(SF33A) viruses. Both mock-immunized and immunized animals became dually infected. Prior immunization preferentially reduced the viral replication of the homologous virus during primary infection but the relative replication of the two...
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