Article

<i>APOE ε4</i> gene dose effect on imaging and blood biomarkers of glial reactivity and β-amyloid pathology

2022-09-20

Abstract excerpt

Increased reactivity of microglia and astrocytes is known to be present at various stages of the Alzheimer’s continuum but their relationship with core Alzheimer’s disease pathology in the preclinical stages is less clear. We investigated glial reactivity and β-amyloid pathology in cognitively unimpaired APOE ε4 homozygotes, heterozygotes and non-carriers using 11 C-PK11195 PET (targeting 18-kDa translocator pro...

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Literature Corpus work: 9167473a-e8a6-5cab-8db8-76e12e228ba6
DOI: 10.1101/2022.09.19.508484

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