Article

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease

2024-11-04

Abstract excerpt

<title>Abstract</title> <p> Experimental evidence suggests that activated microglia induce astrocyte reactivity in neurodegenerative disorders, such as Alzheimer’s disease (AD). Here, we investigated the association between microglial activation and amyloid-β (Aβ) with reactive astrogliosis in the living AD human brain. We studied 101 individuals across the AD spectrum with positron emission tomography (PET) for...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7522537c-b2b4-5573-b2e3-49d6cd38f143
DOI: 10.21203/rs.3.rs-5184011/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s diseaseDOI 10.21203/rs.3.rs-5184011/v1Read

Microglia-Associated Neuroinflammation in Alzheimer’s DiseaseSemantic proximity Read

Alzheimer<sup>’</sup>s-associated inflammatory alterations mediate tau-associated neurodegeneration in limbic and temporal regions across clinical variants of Alzheimer<sup>’</sup>s diseaseSemantic proximity Read

Microglia in Alzheimer’s DiseaseSemantic proximity Read

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progressionSemantic proximity Read

All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer’s diseaseSemantic proximity Read

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s diseaseSemantic proximity Read

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity Read

APOE genotype and astrocyte activity collectively influence AD biomarkers and Aβ burden.Semantic proximity Read

Uncovering Plaque-Glia Niches in Human Alzheimer’s Disease Brains Using Spatial TranscriptomicsSemantic proximity Read

Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic interventionSemantic proximity Read

Integrative multi-omics reveal glial signatures associated with accelerated cognitive decline in Alzheimer’s diseaseSemantic proximity Read

Microglia aggregates define distinct immune and neurodegenerative niches in Alzheimer's disease hippocampus.Semantic proximity Read