Article

<i>APOE</i>ε4 carriership associates with microglial activation independently of Aβ plaques and tau tangles

2022-07-13

Abstract excerpt

Microglial activation is an early phenomenon in Alzheimer’s disease (AD) that may occur prior to and independently of amyloid-β (Aβ) aggregation. Recent studies in transgenic animal models suggest that the apolipoprotein E ε4 ( APOE ε4) allele may be a culprit of early microglial activation in AD. However, it is unclear whether the APOE ε4 genotype is associated with microglial reactivity in the living human brain...

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Literature Corpus work: 03cb7749-1ad7-5be7-a3cb-435725590c9c
DOI: 10.1101/2022.07.12.22277556

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