Article
Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer's disease.
Neurobiology of aging - 1 Aug 2026
Zhu Yalin, Lan Guoyu, Li Anqi, Zhang Laihong, Jiang Mingxing, Yang Jie, Zhu Jiayi, He Zhengbo, Zhou Xin, Li Mingxu, Wang Yiying, Sun Pan, Cai Yue, Liu Zhen, Wang Yan-Jiang, Han Ying, Bu Guojun, Guo Tengfei
Abstract excerpt
Both Apolipoprotein E-ε4 (APOE-ε4) and astrocytic activation, as measured by glial fibrillary acidic protein (GFAP), play critical roles in Alzheimer's disease (AD). However, the influence of astrocytic activation on the relationship between APOE-ε4 and AD pathologies remains unclear. This study investigates the interrelationships among astrocytic activation, APOE-ε4, and AD pathophysiology in 529 participants...
Topics
- Humans
- Glial Fibrillary Acidic Protein
- Alzheimer Disease
- Female
- Apolipoprotein E4
- Biomarkers
- Amyloid beta-Peptides
- Astrocytes
- Male
- tau Proteins
- Aged
- Aged, 80 and over
- Positron-Emission Tomography