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Article

APOE genotype and astrocyte activity collectively influence AD biomarkers and Aβ burden.

Brain research - 15 Jul 2026

Chen Weineng, Su Fengjuan, Kong Haifan, Wang Yating, Yi Chang, Zheng Yifan, Fang Yingying, Shi Xinchong, Lin Yuhao, Zhou Jiayi, Zhang Xiangsong, Pei Zhong

Abstract excerpt

BACKGROUND: The apolipoprotein E ε4 (APOE ε4), a well-established genetic risk factor for Alzheimer's disease (AD), is deeply involved in amyloid-β (Aβ) and tau pathology. Blood-based biomarkers (BBMs), including Aβ42/40, phosphorylated tau (p-tau181), glial fibrillary acidic protein (GFAP) and neurofilament light (NfL), offer accessible proxies of AD pathology. Reactive astrocytes, indicated by elevated GFAP,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41933683
DOI: 10.1016/j.brainres.2026.150283

Genes

APOE
GFAP
ACD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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