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Article

APOE Genotype Modifies the Predictive Performance of Plasma Biomarkers for Amyloid Plaque Burden in Subjective Cognitive Decline.

Journal of Korean medical science - 29 Jun 2026

Lee Hyuk-Je, Yoon Bora, Hong Yun Jeong, Jeong Jee Hyang, Kim SangYun, Wang Min Jeong, Choi Seong Hye, Ryu Ji Sun, Kang Sungmin, Park Kee Hyung, Yang Dong Won

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) ε4 is a well-known risk factor for Alzheimer's disease (AD), with ε4 carriers exhibiting distinct clinical and biological characteristics compared to non-carriers. This study investigated whether the predictive performance of plasma biomarkers for amyloid positron emission tomography (PET) outcomes varies by APOE ε4 carrier status in individuals with subjective cognitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42381527
DOI: 10.3346/jkms.2026.41.e184
PMCID: PMC13320468

Genes

APOE
GFAP
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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