Integration site and clonal expansion in human chronic retroviral infection and gene therapy.

doi:10.3390/v6114140

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Article

Integration site and clonal expansion in human chronic retroviral infection and gene therapy.

Viruses - 31 Oct 2014

Niederer Heather A, Bangham Charles R M

Abstract excerpt

Retroviral vectors have been successfully used therapeutically to restore expression of genes in a range of single-gene diseases, including several primary immunodeficiency disorders. Although clinical trials have shown remarkable results, there have also been a number of severe adverse events involving malignant outgrowth of a transformed clonal population. This clonal expansion is influenced by the integration...

Topics

Cell Proliferation
Chronic Disease
Genetic Therapy
Genetic Variation
Genetic Vectors
Genotype
Humans
Recombination, Genetic
Retroviridae
Retroviridae Infections
Tumor Virus Infections
Virus Integration

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Identifiers

PMID: 25365582
DOI: 10.3390/v6114140
PMCID: PMC4246213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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