Article

Clonality in adult T-cell leukaemia/lymphoma

2014-01-01

Abstract excerpt

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong within the infected host by driving expansion of infected CD4+T-cells. It is the cause of adult T-cell leukaemia/lymphoma (ATL), an aggressive CD4+ T-cell malignancy, which arises in approximately 5% of individuals typically following decades of asymptomatic infection. The reasons why some individuals develop ATL remain unknown. In t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c88ffb4-5d74-5361-91ef-b1d621d91601
DOI: 10.25560/23912

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clonality in adult T-cell leukaemia/lymphomaDOI 10.25560/23912Read

HTLV-1 clonality in natural infectionSemantic proximity Read

Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma.Semantic proximity Read

HTLV-1–infected T cells contain a single integrated provirus in natural infectionSemantic proximity Read

Mutational Intratumor Heterogeneity is a Complex and Early Event in the Development of Adult T-cell Leukemia/Lymphoma.Semantic proximity Read

Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype.Semantic proximity Read

RAISING: a high-performance method for identifying random transgene integration sitesSemantic proximity Read

The relative contributions of infectious and mitotic spread to HTLV-1 persistenceSemantic proximity Read

The molecular and phenotypic signature of human T-cell lymphotropic virus type 1 infected clones and their malignant potentialSemantic proximity Read

Integration site and clonal expansion in human chronic retroviral infection and gene therapy.Semantic proximity Read

Somatic mutation in human T-cell leukemia virus type 1 provirus and flanking cellular sequences during clonal expansion in vivo.Semantic proximity Read

Modelling the diversity and persistence of the human T-lymphotropic virus type-1Semantic proximity Read

Retrovirus insertion site analysis of LGL leukemia patient genomesSemantic proximity Read