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Article

HIV latency and integration site placement in five cell-based models

16 Aug 2013

Abstract excerpt

BACKGROUND: HIV infection can be treated effectively with antiretroviral agents, but the persistence of a latent reservoir of integrated proviruses prevents eradication of HIV from infected individuals. The chromosomal environment of integrated proviruses has been proposed to influence HIV latency, but the determinants of transcriptional repression have not been fully clarified, and it is unclear whether the same...

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PMID: 23953889
DOI: 10.1186/1742-4690-10-90

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